Till Boecking
Till Böcking leads the Molecular Machines Group in the EMBL Australia Node for Single Molecule Science. Originally trained in biochemistry at the University of Bonn in Germany, he crossed disciplines and completed a PhD in Biophysics at UNSW with Hans Coster and Kevin Barrow in 2004. During his doctoral and subsequent postdoctoral research with Justin Gooding and Michael Gal, he developed self-assembly chemistries to assemble biomolecules on surfaces. This work lead to the development of biosensors and the discovery of fundamental principles that govern the performance of these devices. In 2006 he joined the group of Tomas Kirchhausen at Harvard Medical School to elucidate the mechanism of the chaperone-mediated disassembly of the protein coat surrounding endocytic vesicles. Till was awarded a Cross-Disciplinary Fellowship of the Human Frontier Science Program in 2007. Since returning to Australia, Till leads independent research focused on understanding biological processes at the molecular level using approaches from the physical sciences. In particular his team uses single-molecule techniques to resolve mechanistsic questions inaccessible with traditional approaches.
Publications related to this Person
Book Chapters
Böcking T; Upadhyayula S; Rapoport I; Capraro BR; Kirchhausen T, 2018, 'Reconstitution of clathrin coat disassembly for fluorescence microscopy and single-molecule analysis', in Clathrin-Mediated Endocytosis. Methods in Molecular Biology, Humana Press, New York, NY, pp. 121 - 146, http://dx.doi.org/10.1007/978-1-4939-8719-1_10
Boecking T; Gooding JJ, 2007, 'Biomimetic Membranes for Biosensor Applications', in Martin DK (ed.), Nanobiotechnology for Biomimetic Membranes, edn. Original, Springer Publishing Company, USA, pp. 127 - 166
Journal articles
Longatte G; Lisi F; Chen X; Walsh J; Wang W; Ariotti N; Boecking T; Gaus K; Gooding JJ, 2022, 'Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers.', Phys Chem Chem Phys, http://dx.doi.org/10.1039/d2cp03627d
Zuliani-Alvarez L; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Rifat Faysal KM; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, 2022, 'Evasion of cGAS and TRIM5 defines pandemic HIV', Nature Microbiology, vol. 7, pp. 1762 - 1776, http://dx.doi.org/10.1038/s41564-022-01247-0
Yoh SM; Mamede JI; Lau D; Ahn N; Sánchez-Aparicio MT; Temple J; Tuckwell A; Fuchs NV; Cianci GC; Riva L; Curry H; Yin X; Gambut S; Simons LM; Hultquist JF; König R; Xiong Y; García-Sastre A; Böcking T; Hope TJ; Chanda SK, 2022, 'Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA', Molecular Cell, vol. 82, pp. 2871 - 2884.e6, http://dx.doi.org/10.1016/j.molcel.2022.06.010
Brown JWP; Alford RG; Walsh JC; Spinney RE; Xu SY; Hertel S; Berengut JF; Spenkelink LM; Van Oijen AM; Böcking T; Morris RG; Lee LK, 2022, 'Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor', ACS Nano, vol. 16, pp. 6455 - 6467, http://dx.doi.org/10.1021/acsnano.2c00699
Longatte G; Lisi F; Bakthavathsalam P; Böcking T; Gaus K; Tilley RD; Gooding JJ, 2022, 'Biomolecular Binding under Confinement: Statistical Predictions of Steric Influence in Absence of Long-Distance Interactions', ChemPhysChem, vol. 23, http://dx.doi.org/10.1002/cphc.202100765
Zhang MJ; Stear JH; Jacques DA; Böcking T, 2022, 'Insights into HIV uncoating from single-particle imaging techniques', Biophysical Reviews, vol. 14, pp. 23 - 32, http://dx.doi.org/10.1007/s12551-021-00922-6
Johnstone BA; Joseph R; Christie MP; Morton CJ; McGuiness C; Walsh JC; Böcking T; Tweten RK; Parker MW, 2022, 'Cholesterol-dependent cytolysins: The outstanding questions', IUBMB Life, http://dx.doi.org/10.1002/iub.2661
Guinness CM; Walsh JC; Bayly-Jones C; Dunstone MA; Christie MP; Morton CJ; Parker MW; Bocking T, 2022, 'Single-molecule analysis of the entire perfringolysin O pore formation pathway', eLife, vol. 11, http://dx.doi.org/10.7554/eLife.74901
Ni T; Zhu Y; Yang Z; Xu C; Chaban Y; Nesterova T; Ning J; Böcking T; Parker MW; Monnie C; Ahn J; Perilla JR; Zhang P, 2021, 'Structure of native HIV-1 cores and their interactions with IP6 and CypA', Science Advances, vol. 7, pp. eabj5715, http://dx.doi.org/10.1126/sciadv.abj5715
Böcking T; Jacques DA; Lau D; Walsh JC; Dickson CF; Tuckwell A; Stear JH; Hunter DJB; Bhumkar A; Shah V; Turville SG; Sierecki E; Gambin Y, 2021, 'Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy', Analytical Chemistry, vol. 93, pp. 3786 - 3793, http://dx.doi.org/10.1021/acs.analchem.0c04250
Mallery DL; Kleinpeter AB; Renner N; Rifat Faysal KM; Novikova M; Kiss L; Wilson MSC; Ahsan B; Ke Z; Briggs JAG; Saiardi A; Böcking T; Freed EO; James LC, 2021, 'A stable immature lattice packages IP
Renner N; Mallery DL; Faysal KMR; Peng W; Jacques DA; Böcking T; James LC, 2021, 'A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly', PLoS Pathogens, vol. 17, pp. 1 - 22, http://dx.doi.org/10.1371/JOURNAL.PPAT.1009164
Bareja I; Wioland H; Janco M; Nicovich PR; Jégou A; Romet-Lemonne G; Walsh J; Böcking T, 2020, 'Dynamics of Tpm1.8 domains on actin filaments with single-molecule resolution', Molecular Biology of the Cell, vol. 31, pp. 2452 - 2462, http://dx.doi.org/10.1091/MBC.E19-10-0586
Helbig KJ; Bull RA; Ambrose R; Beard MR; Blanchard H; Böcking T; Chua B; Colmant AMG; Crosse KM; Purcell DFJ; Fraser J; Hayward JA; Hamilton ST; Husain M; MacDiarmid R; MacKenzie JM; Moseley GW; Nguyen THO; Quiñones-Mateu ME; Robinson K; Rodrigo C; Rodriguez-Andres J; Rudd PA; Werno A; White P; Young P; Speck P; Hibma M; Drummer HE; Tachedjian G, 2020, 'Tenth scientific biennial meeting of the australasian virology society - AVS10 2019', Viruses, vol. 12, http://dx.doi.org/10.3390/v12060621
Lau D; Walsh JC; Mousapasandi A; Ariotti N; Shah VB; Turville S; Jacques DA; Böcking T, 2020, 'Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders', Langmuir, vol. 36, pp. 3624 - 3632, http://dx.doi.org/10.1021/acs.langmuir.0c00103
Mallery DL; Faysal KMR; Kleinpeter A; Wilson MSC; Vaysburd M; Fletcher AJ; Novikova M; Böcking T; Freed EO; Saiardi A; James LC, 2019, 'Cellular IP
Lau D; Walsh JC; Peng W; Shah VB; Turville S; Jacques DA; Böcking T, 2019, 'Fluorescence Biosensor for Real-Time Interaction Dynamics of Host Proteins with HIV-1 Capsid Tubes', ACS Applied Materials and Interfaces, vol. 11, pp. 34586 - 34594, http://dx.doi.org/10.1021/acsami.9b08521
James LC; Böcking T, 2019, 'Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid', Cell Host and Microbe, vol. 26, pp. 151 - 153, http://dx.doi.org/10.1016/j.chom.2019.07.011
Janco M; Rynkiewicz MJ; Li L; Hook J; Eiffe E; Ghosh A; Böcking T; Lehman WJ; Hardeman EC; Gunning PW, 2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific reports, vol. 9, pp. 11262, http://dx.doi.org/10.1038/s41598-019-47592-9
Marquez CL; Lau D; Walsh J; Faysal KMR; Parker MW; Turville SG; Bocking T, 2019, 'Fluorescence Microscopy Assay to Measure HIV-1 Capsid Uncoating Kinetics in vitro', BIO-PROTOCOL, vol. 9, http://dx.doi.org/10.21769/BioProtoc.3297
Lau D; Walsh J; Peng W; Shah V; Turville S; Jacques D; Böcking T, 2019, 'Fluorescence biosensor for real-time interaction dynamics of host proteins with HIV-1 capsid tubes', , http://dx.doi.org/10.1101/619841
Peng W; Shi J; Márquez CL; Lau D; Walsh J; Faysal KMR; Byeon CH; Byeon IJL; Aiken C; Böcking T, 2019, 'Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A', Retrovirology, vol. 16, http://dx.doi.org/10.1186/s12977-019-0471-4
Battle AR; Norton RS; Böcking T; Noji H; Kim KK; Nagayama K, 2019, 'Editorial: Special issue of Biophysical Reviews dedicated to the joint 10th Asian Biophysics Association Symposium and 42nd Australian Society for Biophysics Meeting, Melbourne, Australia, December 2–6, 2018', Biophysical Reviews, vol. 11, pp. 245 - 247, http://dx.doi.org/10.1007/s12551-019-00553-y
Janco M; Böcking T; He S; Coster ACF, 2018, 'Interactions of tropomyosin Tpm1.1 on a single actin filament: A method for extraction and processing of high resolution TIRF microscopy data', PLoS ONE, vol. 13, pp. e0208586, http://dx.doi.org/10.1371/journal.pone.0208586
Zhao M; Nicovich PR; Janco M; Deng Q; Yang Z; Ma Y; Böcking T; Gaus K; Gooding JJ, 2018, 'Ultralow- and Low-Background Surfaces for Single-Molecule Localization Microscopy of Multistep Biointerfaces for Single-Molecule Sensing', Langmuir, vol. 34, pp. 10012 - 10018, http://dx.doi.org/10.1021/acs.langmuir.8b01487
Márquez CL; Lau D; Walsh J; Shah V; McGuinness C; Wong A; Aggarwal A; Parker MW; Jacques DA; Turville S; Böcking T, 2018, 'Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.34772
Mallery DL; Márquez CL; McEwan WA; Dickson CF; Jacques DA; Anandapadamanaban M; Bichel K; Towers GJ; Saiardi A; Böcking T; James LC, 2018, 'IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.35335
Masedunskas A; Appaduray MA; Lucas CA; Cagigas ML; Heydecker M; Holliday M; Meiring JCM; Hook J; Kee A; White M; Thomas P; Zhang Y; Adelstein RS; Meckel T; Böcking T; Weigert R; Bryce NS; Gunning PW; Hardeman EC, 2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, vol. 131, http://dx.doi.org/10.1242/jcs.212654
Ramdzan YM; Trubetskov MM; Ormsby AR; Newcombe EA; Sui X; Tobin MJ; Bongiovanni MN; Gras SL; Dewson G; Miller JML; Finkbeiner S; Moily NS; Niclis J; Parish CL; Purcell AW; Baker MJ; Wilce JA; Waris S; Stojanovski D; Böcking T; Ang CS; Ascher DB; Reid GE; Hatters DM, 2017, 'Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis', Cell Reports, vol. 19, pp. 919 - 927, http://dx.doi.org/10.1016/j.celrep.2017.04.029
Nicovich PR; Walsh J; Böcking T; Gaus K, 2017, 'NicoLase - An open-source diode laser combiner, fiber launch, and sequencing controller for fluorescence microscopy', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0173879
Nicovich PR; Janco M; Sobey T; Gajwani M; Obeidy P; Whan R; Gaus K; Gunning PW; Coster ACF; Böcking T, 2016, 'Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces', Cytoskeleton, vol. 73, pp. 729 - 738, http://dx.doi.org/10.1002/cm.21342
Sierecki E; Giles N; Bowden Q; Polinkovsky ME; Steinbeck J; Arrioti N; Rahman D; Bhumkar A; Nicovich PR; Ross I; Parton RG; Böcking T; Gambin Y, 2016, 'Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep37630
Janco M; Bonello TT; Byun A; Coster ACF; Lebhar H; Dedova I; Gunning PW; Böcking T, 2016, 'The impact of tropomyosins on actin filament assembly is isoform specific', BioArchitecture, vol. 6, pp. 61 - 75, http://dx.doi.org/10.1080/19490992.2016.1201619
Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K; Liu D; Lee LK; Böcking T, 2016, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site', Nucleic Acids Research, vol. 44, pp. 1411 - 1420, http://dx.doi.org/10.1093/nar/gkv1466
Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19816
Pham S; Tabarin T; Garvey M; Pade C; Rossy J; Monaghan P; Hyatt A; Böcking T; Leis A; Gaus K; Mak J, 2015, 'Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4 receptor induced HIV size expansion prior to cell entry', Virology, vol. 486, pp. 121 - 133, http://dx.doi.org/10.1016/j.virol.2015.09.006
Polling S; Ormsby AR; Wood RJ; Lee K; Shoubridge C; Hughes JN; Thomas PQ; Griffin MDW; Hill AF; Bowden Q; Böcking T; Hatters DM, 2015, 'Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation', Nature Structural and Molecular Biology, vol. 22, pp. 1008 - 1015, http://dx.doi.org/10.1038/nsmb.3127
Böcking T; Aguet F; Rapoport I; Banzhaf M; Yu A; Zeeh JC; Kirchhausen T, 2014, 'Key interactions for clathrin coat stability', Structure, vol. 22, pp. 819 - 829, http://dx.doi.org/10.1016/j.str.2014.04.002
Ngalim SHA; Magenau A; Zhu Y; Tønnesen L; Fairjones Z; Gooding JJ; Böcking T; Gaus K, 2013, 'Creating adhesive and soluble gradients for imaging cell migration with fluorescence microscopy', Journal of visualized experiments : JoVE, http://dx.doi.org/10.3791/50310
Ngalim SH; Magenau A; Zhu Y; Tønnesen L; Fairjones Z; Gooding JJ; Böcking T; Gaus K, 2013, 'Creating adhesive and soluble gradients for imaging cell migration with fluorescence microscopy.', Journal of visualized experiments : JoVE, http://dx.doi.org/10.3791/50310
Boecking T; Kilian KA; Reece PJ; Gaus K; Gal M; Gooding JJ, 2012, 'Biofunctionalization of free-standing porous silicon films for self-assembly of photonic devices', Soft Matter, vol. 8, pp. 360 - 366, http://dx.doi.org/10.1039/c1sm06651j
Le saux G; Magenau AI; Gunaratnam K; Kilian KA; Boecking T; Gooding JJ; Gaus K, 2011, 'Spacing of Integrin Ligands Influences Signal Transduction in Endothelial Cells', Biophysical Journal, vol. 101, pp. 764 - 773, http://dx.doi.org/10.1016/j.bpj.2011.06.064
Le saux G; Magenau AI; Boecking T; Gaus K; Gooding JJ, 2011, 'The Relative Importance of Topography and RGD Ligand Density for Endothelial Cell Adhesion', PLoS ONE, vol. 6, pp. e21869, http://dx.doi.org/10.1371/journal.pone.0021869
Boecking T; Aguet F; Harrison SC; Kirchhausen T, 2011, 'Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating', Nature Structural and Molecular Biology, vol. 18, pp. 295 - 301, http://dx.doi.org/10.1038/nsmb.1985
Boecking T; Kilian KA; Reece PJ; Gaus K; Gal M; Gooding JJ, 2010, 'Substrate independent assembly of optical structures guided by biomolecular interactions', ACS Applied Materials & Interfaces, vol. 2, pp. 3270 - 3275, http://dx.doi.org/10.1021/am1007084
Qiao H; Guan B; Boecking T; Gal M; Gooding JJ; Reece PJ, 2010, 'Optical properties of II-VI colloidal quantum dot doped porous silicon microcavities', Applied Physics Letters, vol. 96, pp. 161106, http://dx.doi.org/10.1063/1.3404183
Xing Y; Boecking T; Wolf M; Grigorieff N; Kirchhausen T; Harrison SC, 2010, 'Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly', European Molecular Biology Organization, vol. 29, pp. 655 - 665, http://dx.doi.org/10.1038/emboj.2009.383
Kilian KA; Lai LH; Magenau AI; Cartland SP; Boecking T; Di Girolamo N; Gal M; Gaus K; Gooding JJ, 2009, 'Smart tissue culture: in Situ monitoring of the activity of protease enzymes secreted from live cells using nanostructured photonic crystals', Nano Letters, vol. 9, pp. 2021 - 2025, http://dx.doi.org/10.1021/nl900283j
Kilian KA; Boecking T; Gooding JJ, 2009, 'The importance of surface chemistry in mesoporous materials: Lessons from porous silicon biosensors', Chemical Communications, pp. 630 - 640, http://dx.doi.org/10.1039/b815449j
Kilian KA; Böcking T; Gaus K; Gooding JJ, 2008, 'Introducing Distinctly Different Chemical Functionalities onto the Internal and External Surfaces of Mesoporous Materials', Angewandte Chemie, vol. 120, pp. 2737 - 2739, http://dx.doi.org/10.1002/ange.200704784
Chilcott TC; Swong E; Boecking T; Coster HG, 2008, 'Electrical characterizations of biomimetic molecular layers on gold and silicon substrates', Physiological Measurement, vol. 29, pp. S307 - S319, http://dx.doi.org/10.1088/0967-3334/29/6/S26
Salomon A; Shpaisman H; Seitz O; Boecking T; Cahen D, 2008, 'Temperature-dependent electronic transport through alkyl chain monolayers: Evidence for a molecular signature', Journal of Physical Chemistry C, vol. 112, pp. 3969 - 3974, http://dx.doi.org/10.1021/0710985b
Kilian KA; Boecking T; Lai LH; Ilyas S; Gaus K; Gal M; Gooding JJ, 2008, 'Organic modification of mesoporous silicon rugate filters: The influence of nanoarchitecture on optical behaviour', INTERNATIONAL JOURNAL OF NANOTECHNOLOGY, vol. 5, pp. 170 - 178, http://dx.doi.org/10.1504/IJNT.2008.016914
Boecking T; Kilian KA; Gaus K; Gooding JJ, 2008, 'Modifying Porous Silicon with Self-Assembled Monolayers for Biomedical Applications: The Influence of Surface Coverage on Stability and Biomolecule Coupling', Advanced Functional Materials, vol. 18, pp. 3827 - 3833, http://dx.doi.org/10.1002/adfm.200800640
Kilian KA; Boecking T; Gaus K; Gooding JJ, 2008, 'Introducing distinctly different chemical functionalities onto the internal and external surfaces of mesoporous materials', Angewandte Chemie (International Edition), vol. 47, pp. 2697 - 2699, http://dx.doi.org/10.1002/anie.200704784
Chou A; Boecking T; Liu R; Singh NK; Moran GM; Gooding JJ, 2008, 'Effect of dialysis on the electrochemical properties of acid-oxidized single-walled carbon nanotubes', Journal of Physical Chemistry C, vol. 112, pp. 14131 - 14138, http://dx.doi.org/10.1021/jp7113785
Ciampi S; Boecking T; Kilian KA; Harper JB; Gooding JJ, 2008, 'Click chemistry in mesoporous materials: Functionalization of porous silicon rugate filters', Langmuir, vol. 24, pp. 5888 - 5892, http://dx.doi.org/10.1021/la800435d
Rapoport I; Boll W; Yu A; Boecking T; Kirchhausen T, 2008, 'A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction', Molecular Biology of the Cell, vol. 19, pp. 405 - 413, http://dx.doi.org/10.1091/mbc.E07-09-0870
Chilcott TC; Coster HGL; Böcking T, 2007, 'Organic-silicon interface', Biophysical Reviews and Letters, vol. 2, pp. 191 - 205, http://dx.doi.org/10.1142/S1793048007000489
Boecking T; Salomon A; Cahen D; Gooding JJ, 2007, 'Thiol-terminated monolayers on oxide-free Si: Assembly of semiconductor-alkyl-S-metal junctions', Langmuir, vol. 23, pp. 3236 - 3241, http://dx.doi.org/10.1021/la063034e
Kilian KA; Boecking T; Gaus K; Gal M; Gooding JJ, 2007, 'Peptide-modified optical filters for detecting protease activity', ACS NANO, vol. 1, pp. 355 - 361, http://dx.doi.org/10.1021/nn700141n
Kilian KA; Ilyas S; Jessup W; Gal M; Gooding JJ; Boecking T; Gaus K, 2007, 'Forming antifouling organic multilayers on porous silicon rugate filters towards in vivo/ex vivo biophotonic devices', Advanced Functional Materials, vol. 17, pp. 2884 - 2890, http://dx.doi.org/10.1002/adfm.200600790
Kilian KA; Boecking T; Gaus K; Gal M; Gooding JJ, 2007, 'Si-C linked oligo(ethylene glycol) layers in silicon-based photonic crystals: Optimization for implantable optical materials', Biomaterials, vol. 28, pp. 3055 - 3062, http://dx.doi.org/10.1016/j.biomaterials.2007.03.014
Kilian KA; Boecking T; Gaus K; King-Lacroix J; Gal M; Gooding JJ, 2007, 'Hybrid lipid bilayers in nanostructured silicon: a biomimetic mesoporous scaffold for optical detection of cholera toxin', Chemical Communications, pp. 1936 - 1938, http://dx.doi.org/10.1039/b702762a
Ilyas S; Boecking T; Kilian KA; Reece PJ; Gooding JJ; Gaus K; Gal M, 2007, 'Porous silicon based narrow line-width rugate filters', Optical Materials, vol. 29, pp. 619 - 622, http://dx.doi.org/10.1016/j.optmat.2005.10.012
Salomon A; Boecking T; Seitz O; Markus T; Amy F; Chan CK; Zhao W; Cahen D; Kahn A, 2007, 'What is the barrier for tunneling through alkyl monolayers? Results from n- and p-Si-Alkyl/Hg junctions', Advanced Materials, vol. 19, pp. 445 - 451, http://dx.doi.org/10.1002/adma.200601729
Ciampi S; Boecking T; Kilian KA; James M; Harper JB; Gooding JJ, 2007, 'Functionalization of acetylene-terminated monolayers on Si(100) surfaces: A click chemistry approach', Langmuir, vol. 23, pp. 9320 - 9329, http://dx.doi.org/10.1021/la701035g
Liu G; Boecking T; Gooding JJ, 2007, 'Diazonium salts: Stable monolayers on gold electrodes for sensing applications', Journal of Electroanalytical Chemistry, vol. 600, pp. 335 - 344, http://dx.doi.org/10.1016/j.jelechem.2006.09.012
Amy F; Chan CK; Zhao W; Hyung J; Ono M; Sueyoshi T; Kera S; Nesher G; Salomon A; Segev L; Seitz O; Shpaisman H; Schöll A; Haeming M; Böcking T; Cahen D; Kronik L; Ueno N; Umbach E; Kahn A, 2006, 'Radiation damage to alkyl chain monolayers on semiconductor substrates investigated by electron spectroscopy', Journal of Physical Chemistry B, vol. 110, pp. 21826 - 21832, http://dx.doi.org/10.1021/jp063614k
Bocking T; Killan KA; Gaus K; Gooding JJ, 2006, 'Single-step DNA immobilization on antifouling self-assembled monolayers covalently bound to silicon (111)', LANGMUIR, vol. 22, pp. 3494 - 3496, http://dx.doi.org/10.1021/la060331a
Boecking T; Wong ELS; James M; Watson JA; Brown CL; Chilcott TC; Barrow KD; Coster HG, 2006, 'Immobilization of dendrimers on Si-C linked carboxylic acid-terminated monolayers on silicon(111)', Thin Solid Films, vol. 515, pp. 1857 - 1863, http://dx.doi.org/10.1016/j.tsf.2006.07.017
Yu JX; Losic D; Marshall M; Boecking T; Gooding JJ; Shapter JG, 2006, 'Preparation and characterisation of an aligned carbon nanotuve array on silicon (100) surface', Soft Matter, vol. 2, pp. 1081 - 1088, http://dx.doi.org/10.1039/b611016a
Salomon A; Boecking T; Gooding JJ; Cahen D, 2006, 'How important is the interfacial chemical bond for electron transport through alkyl chain monolayers', Nano Letters, vol. 6, pp. 2873 - 2876, http://dx.doi.org/10.1021/nl062089y
Seitz O; Boecking T; Salomon A; Gooding JJ; Cahen D, 2006, 'Importance of monolayer quality for interpreting current transport through organic molecules: Alkyls on oxide-free Si', Langmuir, vol. 22, pp. 6915 - 6922, http://dx.doi.org/10.1021/la060718d
Boecking T; Kilian KA; Gaus K; Gooding JJ, 2006, 'Single-Step DNA Immobilization on Antifouling Self-Assembled Monolayers Covalently Bound to Silicon (111)', Langmuir, vol. 22, pp. 3494 - 3496, http://dx.doi.org/10.1021/la060331a
Liu G; Nguyen QT; Chow E; Boecking T; Hibbert DB; Gooding JJ, 2006, 'Study of factors affecting the performance of voltammetric copper sensors based on Gly-Gly-His modified glassy carbon and gold electrodes', Electroanalysis, vol. 18, pp. 1141 - 1151, http://dx.doi.org/10.1002/elan.200603546
Salomon A; Boecking T; Girshevitz O; Cahen D; Kahn A; Chan CK; Amy F, 2005, 'How do electronic carriers cross Si-bound alkyl monolayers?', Physical Review Letters, vol. 95, pp. 266807 - 266810, http://dx.doi.org/10.1103/PhysRevLett.95.266807
Chow E; Wong EL; Boecking T; Nguyen QT; Hibbert DB; Gooding JJ, 2005, 'Analytical performance and characterization of MPA-Gly-Gly-His modified sensors', Sensors and Actuators B - Chemical, vol. 111-112, pp. 540 - 548, http://dx.doi.org/10.1016/j.snb.2005.03.046
Liu G; Liu J; Boecking T; Eggers PK; Gooding JJ, 2005, 'The modification of glassy carbon and gold electrodes with aryl diazonium salt: The impact of the electrode materials on the rate of heterogeneous electron transfer', Chemical physics, vol. 319, pp. 136 - 146, http://dx.doi.org/10.1016/j.chemphys.2005.03.033
Boecking T; Kilian KA; Hanley T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2005, 'The Formation of Tetraethylene Oxide Terminated Si-C Linked Monolayers and their Derivation of with Glycine: An example of a generic strategy for the modification of silicon surfaces with biomolecules', Langmuir, vol. 21, pp. 10522 - 10529, http://dx.doi.org/10.1021/la051191s
Boecking T; Gal M; Gaus K; Gooding JJ, 2005, 'Evidence for why tri(ethylene oxide) functionalized Si-C linked monolayers on Si(111) have inferior protein antifouling properties relative to the equivalent alkanethiol monolayers assembled on gold', Australian Journal of Chemistry, vol. 58, pp. 660 - 663, http://dx.doi.org/10.1071/CH05121
Chou A; Singh NK; Gooding JJ; Boecking T, 2005, 'Demonstration of the importance of oxygenated species at the ends ofcarbon nanotubes for their favourable electrochemical properties', Chemical Communications, pp. 842 - 844, http://dx.doi.org/10.1039/b415051a
Boecking T; Coster HG; James M; Chilcott TC; Barrow KD, 2004, 'Structural characterization of organic multilayers on silicon(111)formed by immobilization of molecular films on functionalized Si-Clinked monolayers', Langmuir, vol. 20, pp. 9227 - 9235, http://dx.doi.org/10.1021/la048474p
Boecking T; Barrow KD; Netting AG; Chilcott TC; Coster HG; Hofer M, 2000, 'Effects of singlet oxygen on membrane sterols in the yeast Saccharomyces cerevisiae', European Journal of Biochemistry, vol. 267, pp. 1607 - 1618, http://dx.doi.org/10.1046/j.1432-1327.2000.01179.x
Conference Papers
Bhumkar A; Gambin Y; Leitao A; Bowden Q; Giles N; Francois B; Hunter D; Boecking T; Sierecki E, 2016, 'What pathological mutants tell us about synuclein aggregation pathways', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444005434&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Bhumkar A; Gambin Y; Leitao A; Bowden Q; Giles N; Francois B; Hunter D; Boecking T; Sierecki E, 2016, 'What pathological mutants tell us about synuclein aggregation pathways', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, presented at Experimental Biology Meeting, CA, San Diego, 02 April 2016 - 06 April 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444003009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
O'Carroll A; Ve T; Lau D; Giles N; Moustaqil M; Bhumkar A; Hunter D; Kobe B; Boecking T; Sierecki E; Gambin Y, 2016, 'Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, presented at Experimental Biology Meeting, CA, San Diego, 02 April 2016 - 06 April 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444003010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
O'Carroll A; Ve T; Lau D; Giles N; Moustaqil M; Bhumkar A; Hunter D; Kobe B; Boecking T; Sierecki E; Gambin Y, 2016, 'Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444005435&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Obeidy P; Sobey TL; Pandzic E; Nicovich PR; Coster A; Gunning P; Boecking T, 2015, 'Actin tropomyosin assembly intermediates', in Actin tropomyosin assembly intermediates, Annual Biophysical Society Meeting, Baltimore (USA), pp. 298a - 298a, presented at Annual Biophysical Society Meeting, Baltimore (USA), 07 February 2015 - 11 February 2015, https://www.cell.com/biophysj/pdf/S0006-3495(14)02828-8.pdf
Al-Zyoud W; Hynson R; Duff A; Sobey T; Lee L; Liu D; Boecking T, 2014, 'Small-Angle X-Ray Scattering Study for Conformational Changes of Unusual Transcription Factor at the Operator', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, pp. 497A - 497A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2013.11.2781
Bowden Q; MacMillan A; Rosenkranz T; Bocking T, 2014, 'Utilising Fluorescence Microscopy to Visualise the Dynamics and Interactions of Molecular Chaperones and alpha-Synuclein', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, pp. 492A - 492A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2664
Kilian KA; Magenau AI; Boecking T; Gaus K; Gal M; Gooding JJ, 2010, 'Silicon-based mesoporous photonic crystals: towards single cell optical biosensors', in Biosensing II. Proceedings of SPIE Volume: 7397, SPIE, San Diego, USA, pp. 739703-1 - 739703-8, presented at SPIE Optics & Photonics, San Diego, USA, 01 August 2010 - 05 August 2010, http://dx.doi.org/10.1117/12.826133
Gooding JJ; Chou A; Boecking T; Hibbert DB; Yu J; Losic D; Shapter JG, 2007, 'The electrochemical performance of electrodes modified with carbon nanotubes', in Joint Symposium of Fundamental Aspects of Nanostructured Materials and Electrocatalysis, Joint Symposium of Fundamental Aspects of Nanostructured Materials and Electrocatalysis, Saspporo, Japan, pp. 22 - 23, presented at Joint Symposium of Fundamental Aspects of Nanostructured Materials and Electrocatalysis, Saspporo, Japan, 02 June 2007 - 23 June 2007
Kilian KA; Boecking T; Ciampi S; Gaus K; Gal M; Gooding JJ, 2007, 'The modification of flat and porous silicon surface with organic monolayers for the capture and detection of biomolecules', in Quake S; Heath JR (ed.), Keystone Symposium on Nanotechnology in Biomedicine, Keystone Symposium on Nanotechnology in Biomedicine, USA, pp. 46 - 46, presented at Keystone Symposium on Nanotechnology in Biomedicine, Tahoe City, USA, 11 February 2007 - 16 February 2007
Yu JX; Losic D; Marshall M; Boecking T; Gooding JJ; Shapter JG, 2007, 'Preparation and characterisation of an aligned carbon nanotube array on silicon (100) surface', in RACI Organic and Physical Chemistry Conference, RACI Organic and Physical Chemistry Conference, Adelaide, Sth Aust, pp. PC30 - PC30, presented at RACI Organic and Physical Chemistry Conference, Adelaide, Sth Aust, 28 January 2007 - 02 February 2007
Chilcott TC; Wong ELS; Böcking T; Coster HGL, 2007, 'Probing biomimetic molecular structures on gold and silicon(111) with electrical impedance spectroscopy', in IFMBE Proceedings, pp. 308 - 311, http://dx.doi.org/10.1007/978-3-540-73841-1_81
Kilian KA; Böcking T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2006, 'Optimisation of nanostructured porous silicon surface chemistry towards biophotonic sensors', in Proceedings of the 2006 International Conference on Nanoscience and Nanotechnology, ICONN, pp. 486 - 489, http://dx.doi.org/10.1109/ICONN.2006.340659
Kilian KA; Boecking T; Ilyas S; Gal M; Gaus K; Gooding JJ, 2006, 'Optimisation of Nanstructured Porous Silicon Surface Chemistry Towards Biophotonic Sensors', in Jagadirh J; Lu M (ed.), International Conference on Nanoscience and Nanotechnology, ICONN 2006: International Conference on Nanoscience and Nanotechnology, Brisbane, Qld, pp. 193 - 193, presented at ICONN 2006: International Conference on Nanoscience and Nanotechnology, Brisbane, Qld, 03 July 2006 - 07 July 2006
Kilian KA; Bocking T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2006, 'Optimisation of Nanostructured Porous Silicon Surface Chemistry Towards Biophotonic Sensors', in 2006 INTERNATIONAL CONFERENCE ON NANOSCIENCE AND NANOTECHNOLOGY, VOLS 1 AND 2, IEEE, AUSTRALIA, Brisbane, pp. 671 - +, presented at International Conference on Nanoscience and Nanotechnology, AUSTRALIA, Brisbane, 03 July 2006 - 07 July 2006, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249051500173&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Böcking T; Ilyas S; Salvador GP; Reece PJ; Gaus K; Gooding JJ; Gal M, 2005, 'Functionalization of porous silicon based photonic crystals with organic monolayers', in Conference on Optoelectronic and Microelectronic Materials and Devices, Proceedings, COMMAD, pp. 217 - 220, http://dx.doi.org/10.1109/COMMAD.2004.1577529
Ilyas S; Reece PJ; Salvador GP; Böcking T; Gal M, 2005, 'Porous silicon based rugate filters', in Conference on Optoelectronic and Microelectronic Materials and Devices, Proceedings, COMMAD, pp. 169 - 172, http://dx.doi.org/10.1109/COMMAD.2004.1577519
Kilian KA; Boecking T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2005, 'Organic Modification of Porous Silicon Photonic Crystals for Biological Sensing Applications', in Apte S; Kable S; Baker AT (eds.), Connect 2005 - Chemical Challenges for the 21st Century, Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, pp. M026 PO Bi/Or - na, presented at Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, 03 July 2005 - 07 July 2005
Gooding JJ; Chou A; Liu J; Boecking T; Singh NK; Hibbert DB; Losic D; Shapter JG, 2005, 'The Self-Assembly of Aligned Carbon Nanotube Arrays for Communicating with Proteins', in Australian Colloid Interface Science Conference 2005, Australian Colloid Interface Science Conference 2005, Coogee, NSW, pp. 85 - -, presented at Australian Colloid Interface Science Conference 2005, Coogee, NSW, 13 February 2005 - 17 February 2005
Boecking T; Ilyas S; Kilian KA; Salvador GP; Reece PJ; Gaus K; Gal M; Gooding JJ, 2005, 'Covalent modification of flat single crystal and porous silicon surfaces for biosensor applications', in Australian Colloid Interface Science Conference 2005, Australian Colloid Interface Science Conference 2005, Coogee, NSW, pp. 149 - 149, presented at Australian Colloid Interface Science Conference 2005, Coogee, NSW, 13 February 2005 - 17 February 2005
Singh NK; Boecking T, 2005, 'Formation of organic monolayers on hydrogen-terminated silicon surfaces via silicon-carbon bond: effect of terminal groups on stability', in 16th National Congress: Physics for the Nation, 16th National Congress: Physics for the Nation, Australian National University, Canberra, presented at 16th National Congress: Physics for the Nation, Australian National University, Canberra, 30 January 2005 - 04 February 2005
Boecking T; Chilcott TC; Coster HG; Barrow KD; James M, 2003, 'Organic monolayers on silicon: electrical impedance spectroscopy methodology towards studying bilayers on silicon', in 5th International Membrane Science and Technology Conference (IMSTEC 03), 5th International Membrane Science and Technology Conference (IMSTEC 03), University of New South Wales, Sydney, Australia, pp. 1 - 6, presented at 5th International Membrane Science and Technology Conference (IMSTEC 03), University of New South Wales, Sydney, Australia, 10 November 2003 - 14 November 2003
Conference Proceedings (Editor of)
Singh NK; Liu R; Boecking T; Gooding JJ, (eds.), 2005, 'Connect 2005 - Chemical Challenges for the 21st Century', Sydney, Convention Centre, Darling Harbour, Sydney, presented at Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, 03 July 2005 - 07 July 2005
Conference Presentations
Chilcott TC; Coster HG; Boecking T; Barrow KD; Hofer M, 1999, 'Implications for membrane structure and function of singlet oxygen mediated oxidation of membrane sterols in the yeast `Saccharomyces cerevisiae`', in 23rd Annual Meeting of the Australian Society for Biophysics, 23rd Annual Meeting of the Australian Society for Biophysics, Gold Coast, Qld, pp. . - ., presented at 23rd Annual Meeting of the Australian Society for Biophysics, Gold Coast, Qld, 30 September 1999
Conference Abstracts
Ghosh A; Janco M; Bocking T; Gunning PW; Lehman W; Rynkiewicz MJ, 2019, 'Structure of the Tpm3.1 N-Terminus: A New Target for Anti-Cancer Treatment', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 116, pp. 253A - 254A, presented at 63rd Annual Meeting of the Biophysical-Society, MD, Baltimore, 02 March 2019 - 06 March 2019, http://dx.doi.org/10.1016/j.bpj.2018.11.1382
Obeidy P; Sobey TL; Pandzic E; Nicovich PR; Coster A; Gunning P; Boecking T, 2015, 'Actin Tropomyosin Assembly Intermediates', in BIOPHYSICAL JOURNAL., CELL PRESS, Vol. 108, pp. 298A - 298A, presented at AACR Special Conference on Advances in Pediatric Cancer Research, http://dx.doi.org/10.1016/j.bpj.2014.11.1619
Kilian KA; Lai LMH; Boecking T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2007, 'Covalently bound biopolymers within mesoporous silicon as improved substrates for optical detection of enzyme activity', in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, IL, Chicago, Vol. 233, pp. 62 - 62, presented at 233rd National Meeting of the Cellulose-and-Renewable-Materials-Division of the American-Chemical-Society (ACS), IL, Chicago, 25 March 2007 - 29 March 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207722805053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Preprints
Faysal KMR; Renner N; Marquez CL; Shah V; Tuckwell AJ; Christie MP; Parker MW; Turville SG; James L; Towers GJ; Jacques DA; Boecking T, 2022, Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure, http://dx.doi.org/10.1101/2022.09.21.508807
Zuliani Alvarez L; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Faysal KMR; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, 2022, Macrophage activation of cGAS and TRIM5 distinguish pandemic and non-pandemic HIV, http://dx.doi.org/10.1101/2022.01.21.477263
Yoh SM; Mamede JI; Lau D; Ahn N; Sánchez-Aparicio MT; Temple J; Tuckwell A; Fuchs NV; Cianci GC; Riva L; Curry H; Yin X; Gambut S; Simons LM; Hultquist JF; König R; Xiong Y; García-Sastre A; Böcking T; Hope TJ; Chanda SK, 2022, Recognition of HIV-1 Capsid Licenses Innate Immune Response to Viral Infection, http://dx.doi.org/10.1101/2022.01.10.472699
Brown JWP; Alford R; Walsh J; Spinney R; Xu S; Hertel S; Berengut J; Spenkelink L; van Oijen A; Böcking T; Morris R; Lee L, 2022, Rapid exchange of stably bound protein and DNA cargo on a DNA origami receptor, http://dx.doi.org/10.1101/2022.01.16.476526
Guinness CM; Walsh J; Bayly-Jones C; Dunstone M; Christie M; Morton C; Parker M; Böcking T, 2021, Single-molecule analysis of the entire perfringolysin O pore formation pathway, http://dx.doi.org/10.1101/2021.10.19.464937
Bareja I; Wioland H; Janco M; Nicovich PR; Jégou A; Romet-Lemonne G; Walsh J; Böcking T, 2020, Dynamics of Tpm1.8 domains on actin filaments with single molecule resolution, http://dx.doi.org/10.1101/2020.06.15.152033
Lau D; Walsh J; Dickson C; Tuckwell A; Stear J; Hunter D; Bhumkar A; Shah V; Turville S; Sierecki E; Gambin Y; Böcking T; Jacques D, 2020, Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy, http://dx.doi.org/10.1101/2020.11.13.382242