Scott Berry wants to uncover the basic mechanisms in a cell involved in controlling gene expression. While DNA encodes the genetic blueprint for development, other factors – including environmental signals, hormones, stress – influence when and how much of these genes are active within our cells.
Stem cells have the potential to develop into any cell type, and which genes are switched on or off at different stages of development ultimately shape their fate.
Scott’s team use new imaging technologies coupled with computational analysis to accurately measure gene expression within individual cells, and visualise many different proteins at a time. Together with statistical analysis methods and mathematical modelling, this approach provides insight into the interplay between gene expression and cell states or fates.
Learn more about research in the Gene Regulation Group.
